Learn > Regenerative Therapies > Prolotherapy & Prolozone Therapy
Ozone Therapy for Musculoskeletal Health
Harnessing Oxygen for Healing
A Practical Overview for Med Spas and Regenerative Clinics
What is Ozone Therapy?
Ozone therapy is a minimally invasive, non-surgical technique that uses medical-grade ozone gas (O₃) to support tissue healing and pain relief. In the med spa and integrative clinic setting, ozone therapy is gaining attention as an innovative option for clients with joint pain, soft tissue injuries, and chronic musculoskeletal complaints. While it is considered experimental and off-label in the U.S., many providers are exploring its benefits as part of a comprehensive regenerative medicine menu.
How Does Ozone Therapy Work?
Ozone therapy is believed to help the body heal itself through several key mechanisms:
Benefit
How It Works
Boosts Oxygen Delivery
Ozone increases oxygen levels in tissues, which may enhance cellular metabolism and energy.
Reduces Inflammation
Ozone can help calm inflammation by modulating immune responses and lowering certain inflammatory markers.
Stimulates Repair
Ozone may activate the body’s natural antioxidant defenses and promote tissue regeneration.
Antimicrobial Effects
Ozone has been shown to kill bacteria and viruses in laboratory settings, though its main use in med spas is for tissue repair.
Who Might Benefit?
Ozone therapy is being explored for a variety of musculoskeletal and wellness concerns, including:
Osteoarthritis (knee, hip, shoulder)
Chronic joint or back pain
Herniated discs (as part of a pain management plan)
Ligament, tendon, and muscle injuries
Recovery after sports injuries or surgery
Chronic fatigue or fibromyalgia (as part of a functional medicine approach)
Why Offer Ozone Therapy in Your Med Spa?
Innovative & Differentiating: Ozone therapy sets your clinic apart as a leader in regenerative and non-surgical solutions.
Non-Pharmaceutical: No systemic medications required—an attractive option for clients seeking natural or drug-free care.
Cash-Based Revenue: Ozone therapy is typically not covered by insurance, making it a profitable, out-of-pocket service.
Synergy with Other Services: Ozone can be combined with prolotherapy, PRP, or physical therapy for enhanced results.
What Does the Research Say?
Pain Relief & Function: Studies suggest ozone injections can reduce pain and improve function in osteoarthritis and chronic joint pain. For example, a 2022 clinical trial found that 70% of patients with knee osteoarthritis reported 35–50% less pain after four ozone treatments, with benefits lasting at least three months.
Safety: When performed by trained professionals, ozone therapy is generally well-tolerated. Most clients experience only mild soreness for a day or two after treatment.
Combination Approaches: Ozone is often used alongside other regenerative therapies, such as prolotherapy or PRP, to maximize healing.
Note: While early results are promising, more large-scale studies are needed. Ozone therapy is not FDA-approved for musculoskeletal use in the U.S.
How Is Ozone Therapy Performed?
Session Length: 15–30 minutes, performed in-office
Number of Sessions: Typically 4–6 treatments, spaced 1–2 weeks apart
Procedure: Ozone gas is injected into or around the affected joint or tissue using sterile technique
Recovery: Most clients can return to normal activities immediately, with only minor post-injection soreness
Sample Protocol for Med Spas
Ozone Concentration: 20–30 μg/mL (adjusted for the specific indication)
Treatment Areas: Knees, shoulders, hips, spine, or soft tissue sites
Bundling: Consider offering ozone therapy as part of a package with PRP, prolotherapy, or physical therapy for added value
FAQs for Wellness Clinics Considering These Therapies
Is ozone therapy profitable?
Yes. It’s a cash-based service with low supply costs and high perceived value.
What training is required?
Providers should complete hands-on ozone therapy workshops and be trained in safe ozone handling and injection techniques.
What equipment do I need?
Ozone generator
Medical-grade oxygen source
Compatible syringes and safety disposables
How do I educate clients?
Use visual aids, printed guides, and webinars to explain ozone therapy as a safe, innovative, and adjunctive option for pain and recovery.
Limitations and Safety
Ozone therapy is considered investigational and is not FDA-approved for musculoskeletal conditions in the U.S. It should only be performed by trained healthcare professionals. While side effects are rare, improper administration can cause tissue irritation or, in very rare cases, more serious complications.
Reviewed by
Stanford Cardiothoracic Surgery
Weekend Health Medical Weight Loss
Disclaimer
This content is for educational and informational purposes only. It does not constitute medical advice or imply that ozone therapy is a substitute for standard care. Ozone therapy is considered off-label in the U.S. and is not approved by the FDA for musculoskeletal treatment. All therapies should be administered under the supervision of a qualified healthcare professional.
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Content provided by MedBio Institute is for educational purposes only and is intended for licensed healthcare professionals. It is not medical advice. Read full disclaimer.